Abstract: Objective: To investigate the application of psycho-cardiology medical mode in patients with coronary artery disease(CAD) and hypertension complicated with psychological disorder.Methods: One hundred and twenty patients with CAD and hypertension complicated with depression and anxiety were randomly divided into the observation group and control group.The observation group and control group were treated with the intervention of psycho-cardiology medical mode based on routine medication and routine medication,respectively.The clinical symptoms,electrocardiogram,blood pressure,scores of Zung self-rating depression/anxiety scale(SDS/SAS),B-type natriuretic peptide(BNP),left ventricular ejection fraction(LVEF) and levels of plasma cortisol,IL-10 and TNFα,and ratio of TNFα to IL-10 in two groups were observed before therapy and after 4 weeks of therapy.Results: The clinical symptoms,electrocardiogram,blood pressure,scores of SDS and SAS,BNP JNFα and LVEF in two groups were improved after therapy(P<0.05 to P<0.01).The levels of IL-10 in two groups increased after therapy,the increasing degree of which in observation group were more than which in control group(P<0.05).The levels of cortisol in two groups decreased after therapy,the decreasing degrees of whose in observation group were more than whose in control group(P<0.05).Conclusions: The treatment of patients with CAD and hypertension complicated with psychological disorder with psycho-cardiology medical mode can improve the clinical effects,the related mechanisms of which are associated with the role of plasma cortisol and imbalance between inflammation and anti-inflammation.