Abstract: Objective: To compare the amnesia effect of midazolam and droperidol used as an adjuvant during epidural blockade in surgical patients.Methods: Thirty-eight patients(ASA Ⅰ-Ⅱ)were randomly divided into midazolam groups and droperido group(19 cases in each).After epidural blockade was established,midazolam 3 mg and meperiding 50 mg were infused to the midazolam group(group A),while droperidol2.5 mg and meperiding 50 mg were infused to the droperido group(group B).The amnesia effect was observed in both groups during 24 hours after operation.Results: The rate of amnesia reached 95.0% in group A,but only 21.1% in group B;the difference was significant(P<0.001).Conclusions: Midazolam used as adjuvant during epdural blockade has a better amnesia effect.