Objective To investigate the association between triglyceride-glucose index (TyG) and risk of readmission for heart failure (HF).

Methods The HF patients were selected as the research subjects, and the baseline data, laboratory examination indicators and echocardiographic parameters of patients were collected. The patients were divided into the high TyG group (T3 group, ＞8.79), medium TyG group (T2 greoup, ＞8.25 and ≤8.79) and low TyG group (T1 grouyp, 8.25) according to the terles of TyG index. The primary outcome was readmission due to HF after 3 months of discharge. Kaplan-Meier survival analysis and Cox regression analysis were used to evaluate the association between the TyG index and risk of re-hospitalization due to heart failure within 3 months in patients.

Results A total of 323 HF patients were enrolled in the study, among whom 133 (41.2%) were female and 87 (26.9%) had coronary heart disease. In T3 group, the proportion of females, body mass index, incidence rates of coronary heart disease, hypertension and diabetes, total cholesterol,low-density lipoprotein and usage rates of SGLT-2 inhibitors were higher, and the left ventricular ejection fraction and amino-terminal pro-B-type natriuretic peptide were lower. The results of Kaplan-Meier survival analysis showed that the readmitted risk in the T3 group was significantly higher than that in T1 group. The resulst of Cox regression analysis showed that for every one standard deviation increase (0.60) in the TyG index, the risk of readhospitalization increased by 76% (HR: 1.760, 95%CI: 1.436, 2.157), and compared with T1 group, the risk of readhospitalization at 3 months in T3 group was 2.96 times higher (95%CI: (1.671, 5.046). After adjusting the potential confounding factors, this association remained independent.

Conclusions The higher the TyG index, the greater the 3-month readmission risk for HF patients, and the TyG index is an important predictor of HF patients early readmission.