Abstract: Objective: To investigate the correlations of the levels of homocysteine(Hcy) and high-sensitive C-reactive protein(hs-CRP) and cerebral infarction.Methods: One hundred and twenty patients with cerebral infarction(including 72 cases complicated with hypertension and 48 cases complicated without hypertension) and 130 healthy people were divided into the experiment group and control group,respectively.The levels of Hcy and hs-CRP of all cases was detected.Results: The levels of Hcy and hs-CRP in experiment group(22.1±6.3)mg/L and(9.4±2.6)mg/L were higher than those in control group(10.4±2.5)mg/L and(1.8±0.8)mg/L(P<0.01).The levels of Hcy and hs-CRP in cerebral infarction patients complicated with hypertension((31.4±8.5)mg/L and(13.7±4.9)mg/L were higher than those in cerebral infarction patients complicated without hypertension(23.4±4.6)mg/L and(10.7±4.3) mg/L(P<0.01).Conclusions: The levels of Hcy and hs-CRP are closely related with the occurrence and development of cerebral infarction,which has importantly clinical value in cerebral infarction patients.