结直肠癌组织中CD44v6及nm23的表达与淋巴、肝转移的关系探讨

Association of CD44v6 and nm23 protein expression in colorectal cancer tissues with lymph and liver metastases

摘要: 目的:探讨CD44v6、nm23在结直肠癌组织中的表达及其与肝脏、淋巴结转移的关系。方法:随机抽取2005~2008年结直肠癌手术标本159例,均经免疫组织化学检测,分析CD44v6、nm23与肿瘤分化及淋巴、肝转移等情况的关系。结果:结直肠癌组织中CD44v6、nm23的表达与淋巴、肝转移有一定的联系(P<0.05~P<0.01)。结论:CD44v6、nm23可以有效地预测结直肠癌转移,特别是肝转移发生的潜能,从而判断结直肠癌的预后。

Abstract: Objective: To study the role of CD44v6 and nm23 in predicting colorectal metastases,especially the liver metastases.Methods: One hundred and fifty-nine cases of colorectal cancer received the immunohistochemical detection in our hospital from 2005 to 2008 randomly selected.The association of CD44v6 and nm23 with tumor differentiation,as well as lymph and liver metastasis was studied.Results: The expression of CD44v6 and nm23 in colorectal cancer was closely linked with the lymph nodes and liver metastases(P<0.05 to P<0.01)Conclusions: CD44v6 and nm23 can efficiently predict the colorectal metastases,especially the incidence of liver metastases,which may help to determine the prognosis of patients with colorectal cancer.