两种剂量免疫球蛋白治疗川崎病疗效探讨

Treatment of Kawasaki disease with intravenous immuneoglobulin in two different doses

摘要: 目的: 探讨不同剂量免疫球蛋白(IVIG)静脉滴注治疗小儿川崎病的疗效。方法: 回顾性总结1995~2003年收治的41例川崎病患儿治疗情况。结果: 17例川崎病应用IVIG 1 g/kg,分400~500 mg·kg^-1·d^-1×2~3天和22例IVIG 2 g/kg,分400 mg·kg^-1·d^-1×5天治疗,在退热时间、白细胞下降至正常、冠状动脉(CA)扩张等方面差异均无显著性(P=1.000)。结论: IVIG治疗小儿川崎病,1 g/kg和2 g/kg疗效相当,推荐应用IVIG 1 g/kg,以节约药源和患者治疗费用。

Abstract: Objective: To explore the efficacy of different doses' of IVIG in treatment of Kawasaki disease.Methods: The data of 41 cases of Kawasaki disease admitted to our hospital from 1995 to 2003 were reviewed.Results: Seventeen cases were treated with IVIG 1g/kg(400-500 mg·kg^-1·d^-1,for 2-3 days).22 cases with IVIG 2 g/kg(400 mg·kg^-1·d^-1 for 5 days).There was no obvious difference between the two groups(P=1.000) in the lasting time of fever,blood white cell count,and coronary artery dilation(CAD).Conclusions: The efficacy of two different dose of IVIG is almost equal in treatment of Kawasaki disease.We suggest that 1 g/kg IVIG be used to save the drug resource and reduce the cost.