多西他赛周剂量治疗老年晚期贲门癌28例

Weekly docetaxel for treatment of advanced gastric cardia cancer in the elderly:a report of 28 cases

摘要: 目的:观察多西他赛周剂量治疗老年晚期贲门癌临床疗效。方法:28例老年晚期贲门癌患者,予多西他赛35mg/m²,静脉滴注,第1、8、15天给药,每28天为1周期。完成2周期后评价疗效,有效及稳定病例完成4周期。结果:28例均可进行评价,完全缓解0例,部分缓解10例,无变化6例,进展12例,总有效率35.7%,临床获益57.1%,不良反应以Ⅰ~Ⅱ度粒细胞减少、乏力、脱发为主。结论:多西他赛周剂量治疗老年晚期贲门癌疗效较好,患者耐受性也较好。

Abstract: Objective:To observe the efficacy of weekly administration of domestic docetaxel on advanced cardia cancer in the elderly.Methods:Twenty-eight elderly patients with advanced cardia cancer receiving chemotherapy were treated with domestic docetaxel in the dose of 35 mg/m² on day 1,8 and 15 every 28 days.Evaluation was performed after two cycles,and the patients who did not respond went through another two cycles.Results:All the 28 cases were evaluated.CR was observed in 0 cases,PR in 10 cases,SD in 6 cases and PD in 12 cases,with a response rate of 35.7%.Clinical benefit was achieved in 57.1% of the cases.The common toxicities were Ⅰ to Ⅱ degree neutropenia,aneamia and shed-hair.Conclusions:Weekly domestic docetaxel shows good efficacy in treatment of advanced cardia cancer in the elderly,and the patients tolerate well.