Abstract: Objective: To investigate the influential factors of feeding intolerance in premature infant and to find strategies for the prevention of feeding intolerance.Methods: The relationships among feeding intolerance and birth weight,gestation,and timing of feeding initiation of about 130 premature infant in our hospital from January 2005 to July 2006 were analyzed retrospectively.Results: The total rate of feeding intolerance in premature infant was 30 percent.There was no significant difference found between birth weights of ≤ 1 500 g and >1 500 g(P>0.05).Further,there was no significant difference found between gestation periods of ≤ 34 and >34 weeks,although for ≤ 36 a difference was found(P>0.05).As for the timing of feeding initiation,a significant difference was found between times of >2 days and ≤ 2 days(P<0.05).Asphyxia,other complications,and gestational disease in the mother were not associated with feeding intolerance.Conclusions: Feeding intolerance occurs more easily in neonates with later feeding initiation.The early right feeding can reduce the premature infant dependence of parenteral natrintion and improve the living quality of the premature infant.