Abstract: Objective: To improve the diagnosis and treatment of primary Sjögren's syndrome (pSS) by analyzing the clinical features of the disease.Methods: The clinical data and related laboratory tests of 75 pSS patients were reviewed.Results: The primarily incipient symptoms of pSS were arthralgia 54 cases,dry mouth 51 cases,dry eyes 44 cases,decayed tooth 20 cases,febrile 19 cases,dysphagic 15 cases and parotid enlargement 13 cases.Laboratory testes showed that 27 cases of the patients developed anemia,26 cases leucopenia and 11 cases thrombocytopenia.Patients with positive anti-SSA or anti-SSB antibodies had a higher incidence of dry mouth and neutropenia than those with negative auto-antibodies (P<0.05).Conclusions: The onset symptoms of pSS are diverse.It is easy to make misdiagnosis or missed diagnosis.Comprehensive clinical symptoms and laboratory tests should be included in making correct diagnosis of pSS.