纳络酮治疗中、重度新生儿缺氧缺血性脑病临床疗效分析

    Clinical analysis of curative effect of Naloxone in treatment of neonates with middle or severe hypoxic-ischemic encephalopathy

    • 摘要: 目的: 探讨纳络酮治疗中、重度新生儿缺血缺氧性脑病(HIE)的临床疗效。方法: 中、重度新生儿HIE在传统治疗基础上,治疗组20例加用纳络酮治疗5~7天,并与对照组12例在生命体征、意识、反射、肌张力恢复时间、主要症状体征恢复时间及治疗转归进行比较。结果: 治疗组体温、呼吸改善明显优于对照组,意识、肌张力恢复时间、主要症状体征恢复时间短于对照组,总有效率(90%)高于对照组(50%)(P=0.030)。结论: 纳络酮治疗可提高中、重度HIE疗效,未见副作用发生。

       

      Abstract: Objective: To investigate the curative effect of naloxone in treatment of neonates with middle or severe hypoxic-ischemic encephalopathy (HIE). Methods: Based on the traditional therapy, naloxone was added to treat 20 neonates with middle or severe HIE and compared the curative effect with 12 controls. The indexes included vital signs, resumption time of consciousness, reflex and muscular tension, sustaining time of main symptoms and signs, and curative outcome. Results: Compared with controls, patients treated with naloxone showed better vital signs, their resumption time of consciousness and muscular tension were shoter, as well as their sustaining time of main symptoms and signs. Total effective rate of management group was higher than control group (P=0.030). Conclusions: Naloxone plays an important role in treating neonates with middle or severe HIE, elevates curative effect and has no side effects.

       

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