Objective To investigate the correlations between the neutrophils (Nen), hgh sensitivity C-reactive protein (hs-CRP) and consciousness disturbance in patients with acute ischemic stroke (AIS).

Methods Two hundred and twenty-eight patients with AIS were selected. The clinical data and Neu count, Neu percentage, lymphocyte (Lym) count, Lym percentage, neutrophil to lymphocyte ratio (NLR) and hs-CRP were compared between consciousness disturbance group and no consciousness disturbance group. The correlations between the Neu count, Neu percentage, Lym count, Lym percentage, NLR, hs-CRP and GCS score in AIS patients were analyzed.

Results The Neu count, Neu percentage and hs-CRP in the consciousness disturbance group were higher than those in no consciousness disturbance group (P ＜ 0.01), and the proportion of patients with atrial fibrillation in the consciousness disturbance group was higher than that in no consciousness disturbance group (P ＜ 0.01). In AIS patients without atrial fibrillation, the Neu count, Neu percentage and hs-CRP in patients with consciousness disturbance were significantly higher than those without consciousness disturbance (P ＜ 0.01), and the Lym count and percentage in patients with consciousness disturbance were significantly lower than those without consciousness disturbance (P ＜ 0.01). Among AIS patients with and without AIS, the differences of Neu count, Neu percentage and hs-CRP among patients with different degree of consciousness disturbance were statistically significant (P ＜ 0.05 ~ P ＜ 0.01). Among AIS patients with and without atrial fibrillation, the Neu count, Neu percentage and hs-CRP were negatively correlated with GCS score (P ＜ 0.05).

Conclusions The Neu count, Neu percentage and hs-CRP in AIS patients with consciousness disturbance increase, and the Neu count, Neu percentage and hs-CRP are negatively correlated with GCS score.