血清肌酐、尿素氮及尿酸对妊娠期糖尿病肾功能的评价作用

The value of serum uric acid,blood urea nitrogen and creatinine in the evaluation of renal function of gestational diabetes melltius

摘要: 目的: 探讨血清肌酐(Scr)、尿素氮(BUN)及尿酸(UA)的检测在诊断妊娠期糖尿病(GDM)患者肾功能损害中的价值。方法: 选择待产分娩的GDM住院患者99例(GDM组), 随机选择同期住院的正常妊娠孕妇99例为对照组。对Scr、BUN、UA 3项指标进行比较。结果: GDM组血清UA水平均较对照组明显升高(P<0.01);2组血清BUN和Scr水平差异均无统计学意义(P>0.05)。GDM组UA值异常发生率明显高于对照组(P<0.01)。结论: 血清UA水平的异常升高可能是GDM肾功能早期损害的敏感指标。

Abstract: Objective: To investigate the value of serum creatinine(Scr),blood urea nitrogen(BUN) and serum uric acid(UA) in the evaluation of the renal injury of gestational diabetes mellitus(GDM) patients.Methods: Ninty-nine labor and delivery patients with GDM and 99 normal pregnancy women were divided into the GDM group and control group,respectively.The levels of Scr,BUN and serum UA between two groups were compared.Results: The UA level in the GDM group was significantly higher than that in the control group(P<0.01).The differences of the levels of BUN and Ser between two groups were not statistically significant(P>0.05).The incidence of UA abnormality in GDM group was significantly higher than that in the control group(P<0.01).Conclusions: The abnormal increase of serum UA level may be a sensitive indicator of early damage of renal function in GDM.