Abstract: Objective: To investigate the influence of high-flux dialysis(HFD) on resistant hypertension in patients with uremia.Methods: Thirty cases with resistant hypertension in uremia patients were randomly assigned to observation group and control group.Low flux dialyzers were used in control group and high flux dialyzers were used in observation group.The dialysis time was 12 hours every week and the observation duration was 12 weeks.The changes of systolic blood pressure,diastolic blood pressure and mean arterial pressure in the two groups before and after treatment were observed.Results: The decrease degrees of systolic blood pressure,diastolic blood pressure and mean arterial pressure in observation group were superior than in control group after 12 weeks,which had statistical significances(P<0.01).Conclusions: HFD mode can effectively improve resistant hypertension in uremia patients.