Abstract: Objective: To summarize the experience intreatment of phlegmasia cerulea dolens (PCD) and to explore the optimal therapy.Methods: The clinical data of 12 cases of PCD were retrospectively analyzed,11 cases were treated surgically,the surgical procedures included simple thrombectomy in 4 limbs,inferior vena cava filter placement+thrombectomy in 2 limbs,inferior vena cava filter placement +thrombectomy+left iliac vein balloon angioplasty in 5 limbs.Only one patient received anticoagulation and thrombolysis.Results: All surgery in 11 cases were sucessful,no severe postoperative complications occurred,all the patients were cured of their symptoms,there was pulmonary embolism,amputation or death.The pulsation of dorsal artery was found overnight,and the limb was almost normal after 8 days in anther patient receiving conventional treatment.Conclusions: Thrombectomy combined prompt and full dosage of anticoagulation is safe,effective,and economical for treatment of PCD.