Rb/p16路径在非小细胞肺癌中的表达意义

Rb/p16 pathway in non-small-cell lung cancers

摘要: 目的: 探讨Rb和p16基因在非小细胞肺癌(NSCLC)中的表达及其与临床病理因素的关系。方法: 采用免疫组化SP法检测80例NSCLC组织中Rb和p16的表达。结果: 在80例NSCLC组织中,分别有56例和47例显示Rb和p16表达缺失。两者之间有一定相关(P<0.05)。p16在鳞状细胞癌比腺癌中有较高的表达(P<0.05),而Rb蛋白的表达异常与肿瘤分期有关(P<0.05)。结论: Rb/p16路径的中断在肺癌的发生发展中是常见事件。

Abstract: Objective: To investigate the expression of Retinoblastoma(Rb)and p16 in non-small-cell lung cancer(NSCLC)and their relationship to clinicopathological factors.Methods: Eighty cases of NSCLC were studied for expression of Rb and p16 by immunohistochemical technique SP method.Results: Fifty-six(70.00%)and 47(58.75%)cases of 80 patients revealed loss of protein expression for RB and p16 respectively.The correlation was found between Rb and p16(P<0.05).Loss of p16 expression was noted in most squamous and in a small fraction of adenocarcinomas(P<0.05).Notably,loss of Rb expression was associated with T stage(P<0.05).Conclusions: Our results suggest that disruption of Rb/p16 pathway is frequently invoved in NSCLC.