Abstract: Objective:To study the expressions of CD147,Matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor (VEGF) in renal cell carcinoma(RCC),and explore their correlations with tumor growth,tumor invasion and metastasis. Methods:The expressions of CD147,MMP-9 and VEGF were detected by immunohistochemical SP method in tissue from the carcinoma(RCC,n=107) and normal renal tissue (n=10). The relationships between the expressions and clinical pathology were analyzed, and the correlations among CD147, MMP-9 and VEGF were studied. Results:The expressions of CD147, MMP-9 and VEGF in RCC were significantly higher than those in normal renal tissue(P<0.01),which had no statistical significance related to pathological type(P>0.05),but had statistical significances related to clinical staging(P<0.01). A positive correlation among CD147,MMP-9 and VEGF was observed(P<0.01). Furthermore,the expression of CD147 was statistical significance associated with tumor size,clinical stage and distant metastasis(P<0.01),but not with age and gender(P>0.05). Conclusions:CD147,MMP-9 and VEGF play the important role in the progression and invasion in RCC,the detection of CD147,MMP-9 and VEGF expressions may be the potential biological indexes which reflect tumor growth,invasion and metastasis of RCC.