Abstract: Objective: To explore the association of subclinical diabetic peripheral neuropathy with glycosylated hemoglobin and the course of the disease.Methods: The nerve conduction velocity and somatosensory evoked potential test were performed in 102 diabetic patients with no lower extremity peripheral neuropathy symptoms or signs to detect the subclinicct diabetdeteic peripheral neuropathy;the correlation between the subclinical diabetic peripheral neuropath,the course of the disease and the glycosylated hemoglobin were analyzed statistically.Results: Abnormal nerve conduction velocity and somatosensory evoked potential test results were found in 37 of the 102 cases,which was somewhat associated with glycated hemoglobin and the course of the disease (P<0.01 and P<0.05).Conclusions: Detection of the nerve conduction velocity and somatosensory evoked potential testing can help to early diagnosis of subclinical peripheral neuropathy,and long course of disease and high glycosylated hemoglobin might increase the incidence of subclinical peripheral neuropath.