乳腺癌STAT3蛋白表达及其临床意义

Expression of STAT3 in breast cancer and its clinical significance

摘要: 目的:探讨STAT3蛋白在乳腺癌组织中的表达及其与乳腺癌临床病理参数的关系。方法:应用免疫组化法检测30例正常乳腺组织、76例乳腺癌组织中STAT3蛋白的表达,观察其与乳腺癌预后的关系。结果:STAT3蛋白在正常乳腺组织中的阳性表达率是23.3%,低于乳腺癌组织中的65.8%(P<0.01);STAT3蛋白的表达与乳腺癌的临床分期、细胞分化程度和淋巴结转移均有一定关系(P<0.05)。结论:STAT3蛋白在乳腺癌中的高表达可能是判断乳腺癌预后不良的指标之一。

Abstract: Objective: To investigate the expression of STAT3 in breast carcinoma and its relation with prognosis.Methods: The expression of STAT3 in 30 normal breast tissues and 76 cases of breast carcinoma was determined using immunohistochemical staining S-P method,and its association with prognosis was analyzed.Results: The positive expression of STAT3 in normal breast tissues(23.3%) was significantly lower than that in breast carcinoma(65.8%) (P<0.01).The expression of STAT3 in breast carcinoma was significantly associated with the surgical stage,differentiation and lymphatic invasion(P<0.05).Conclusions: High expression of STAT3 is associated with poor prognosis of breast carcinoma.