Abstract: Objective: To investigate the efficacy of different blood purification techniques on acute renal failure.Methods: Twenty-five patients with severe acute renal failure,11 of whom suffered from mutliple organ dysfuction syndrome,were treated by intermitten hemodialysis(IHD),continuous hemodiafiltration(CVVHDF) and plasma exchange(PE).The predialysis and postdialysis serum urea nitrogen,creatinine and bilirubin were measured.The results were analysed and compared.Results: The total mortality was 24.0%.IHD was more effective in eliminating serum urea nitrogen and creatinine than CVVHDF or PE,while PE had better effect in eliminating bilirubin than CVVHDF or IHD.Conclusions: The combined therapy of IHD,CVVHDF and PE may reduce mortality of acute renal failure.