Abstract: Objective: To investigate the clinical features and treatment of young patients with primary liver cancer (PLC).Methods: A total of 80 cases of PLC were divided into 2 groups,young group (age<40 years),24 cases;non-young group (age ≥ 40 years),56 cases.The clinical symptoms,clinicopathologic features,clinical conditions of liver and the incidence of postoperative complications in the two groups were comparatively analyzed.Results: The cases in young group have less specific clinical manifestations than the cases in non-young group (P<0.05-P<0.01);cholangiocarcinoma in the young group are less than that in non-young group (P<0.05),young group has a better liver fuction than that of non young group (P<0.01).Postoperative complications rate in young group is lower than in non-young group (P<0.05).Conclusions: Occult liver cancer onset,low early diagnosis and high operation tolerance occur in young PLC patients;surgery-predominant comprehensive therapy should be performed for young PLC patients to improve outcome.Low incidence of postoperative complications were also noted in young PLC patients.