ObjectiveTo explore the value of serum carbohydrate antigen 724(CA724) and human epididymis protein 4(HE4) in the diagnosis of pregnant women with ovarian cancer, and their correlation with ultrasound contrast parameters.

MethodsSixty-eight pregnant women with ovarian cancer and 200 normal pregnant women were divided into the observation group and control group, respectively.The serum levels of CA724 and HE4 in two groups were detected, and the relationship between the above indicators and ovarian cancer in pregnant patients were analyzed. The correlation between CA724, HE4 and contrast-enhanced ultrasound parameterstime to peak(TTP) and enhanced intensity(EI) after termination of pregnancy in the observation group with different pathological characteristics were analyzed.

ResultsThe serum levels of CA724 and HE4 in observation were higher than those in control group(P < 0.01). The serum CA724 and HE4 were positively correlated with ovarian cancer in pregnancy(P < 0.05). The area under the curve(AUC) of the combined diagnosis of serum CA724 and HE4 in pregnancy with ovarian cancer was 0.940, and the diagnostic sensitivity and specificity of the combined detection of CA724 and HE4 were 88.24% and 92.00%, respectively. The differences of the levels of CA724, HE4, EI and TTP among the observation group with different FIGO stages, degree of differentiation and depth of invasion were statistically significant(P < 0.05 to P < 0.01). The serum CA724 and HE4 levels in observation group were positively correlated with EI, FIGO stage and invasion depth(P < 0.05 to P < 0.01), and negatively correlated with TTP and differentiation degree(P < 0.05 to P < 0.01).

ConclusionsThe serum CA724 and HE4 levels increase significantly in pregnant patients with ovarian cancer, which can help the clinical diagnosis of pregnancy with ovarian cancer, and is closely related to the parameters of ultrasound contrast after pregnancy termination, ovarian cancer stage, depth of invasion and differentiation degree.