Abstract: Objective: To determine the clinical effects of local insulin injection combined with synthetic dressing on treatment of stage Ⅲ pressure sore in diabetic patients.Methods: A total of 32 cases,which had placed on admission with stage Ⅲ pressure sore were randomly divided into two groups.The patients in control group were received synthetic dressing on the basis of routine nursing and diet.The patients in experimental group were received insulin injection combined with synthetic dressing on the basis of routine nursing and diet.The clinical effects were compared after 21-day observation.Results: The average time of wound healing in experimental group was significantly lower than in control group(P<0.01),the wound healing rates in different periods were also significantly higher than in control group(P<0.05 to P<0.01).At the same time,the blood sugar level in experimental group had no obvious change after local application of insulin.Conclusions: Local insulin injection combined with synthetic dressing can reduce the healing time of stage Ⅲ pressure sore,meanwhile it is economic,safe,and no side effects.