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    RBBP7与PBX1在食管鳞癌中表达及与放疗预后关系的研究

    Study on the expression levels of RBBP7 and PBX1 in esophageal squamous cell carcinoma and their relationship with radiotherapy prognosis

      摘要
    • 摘要:
      目的： 探讨视网膜母细胞瘤结合蛋白7（RBBP7）和前B细胞白血病同源框转录因子1（PBX1）在食管鳞癌中表达及其与食管鳞癌放疗病人预后的相关性。
      方法： 收集接受放疗的食管鳞癌病人175例，采用免疫组织化学法检测食管鳞癌组织中RBBP7、PBX1表达，分析RBBP7与PBX1表达的相关性及二者与病人预后的相关性。
      结果： 免疫组织化学染色结果显示，RBBP7在食管鳞癌组织细胞核中高表达，PBX1在细胞质和细胞核表达。175例ESCC病人病理组织标本中RBBP7阳性表达91例，阴性表达84例；PBX1阳性表达87例，阴性表达88例。Spearman分析显示，RBBP7与PBX1表达呈明显负相关关系（P ＜ 0.01）。RBBP7表达阳性和阴性病人中位生存时间差异有统计学意义（P ＜ 0.05），PBX1表达阳性和阴性病人中位生存时间差异无统计学意义（P ＞ 0.05）。多因素COX回归分析结果显示，RBBP7、是否合并化疗均为病人总生存期的独立影响因素（P ＜ 0.05）。
      结论： RBBP7有助于预测食管鳞癌放疗病人预后，可能是食管鳞癌病人放疗的潜在靶点。

       

      Abstract:
      Objective To investigate the expression levels of retinoblastoma-binding protein 7(RBBP7) and pre-B-cell leukemia homeobox transcription factor-1 (PBX1) in esophageal squamous cell carcinoma (ESCC) and their correlation with the prognosis of ESCC patients treated with radiotherapy.
      Methods The expression levels of RBBP7 and PBX1 in ESCC tissues of 175 ESCC patients treated with radiotherapy were detected using immunohistochemistry. The correlation between RBBP7 and PBX1, and between the two and prognosis of patients were analyzed.
      Results The results of immunohistochemical staining showed that RBBP7 was highly expressed in the nucleus of ESCC, and PBX1 was expressed in cytoplasm and nucleus. There were 91 positive and 84 negative expressions of RBBP7 in pathological tissue samples of 175 ESCC patients, and the PBX1 expression was positive in 87 cases, and negative in 88 cases. The results of Spearman analysis showed that there was a significantly negative correlation between RBBP7 and PBX1 expression (P ＜ 0.01). The difference of the median survival time between patients with positive and negative expression of RBBP7 was statistically significant (P ＜ 0.05), while there was no statistically significant difference in the median survival time between patients with positive and negative expression of PBX1 (P ＞ 0.05). The results of multivariate COX regression analysis showed that RBBP7 and whether chemotherapy was combined were the independent influencing factors of overall survival (P ＜ 0.05).
      Conclusions RBBP7 is helpful to predict the prognosis of ESCC patients treated with radiotherapy, and may be a potential target for radiotherapy.

       

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