Abstract: Objective:To investigate the application of locking plate in treatment of the extremities fracture.Methods:Forty-five cases (51 fractures) of the extremities fracture were treated with less invasive stabilization system (LISS) or locking compress plate (LCP) by indirect reestablishment and minimally invasive techniques.Twenty-two patients with distal femoral or proximal tibial fractures were treated with LISS,and the others were treated with LCP.Results:All the cases were followed up for 1-17 months.No wound infection,delayed union,bone nonunion,loss of height of articular surface,displaced or angulationfracture,screw extraction or plate fragmentation occurred.The healing time of the fracture was 8-16 weeks.The patients were able to walk without support or grip after 12-16 weeks.The function of all the extremities restored well.Conclusions:Treatment of extremities fracture using locking plate with minimally invasive plate osteosynthesis techniques has the advantages of less soft tissue trauma,less damage to the blood vessel of the bone or periosteum,lower infection rate,rapid union and satisfactory function recovery.