基于血管新生情况探讨中风痰瘀汤对急性缺血性脑卒中病人PDGF-BB、Ang-2表达的影响

鹿俊磊; 杨晓芳; 秦朝娟

基于血管新生情况探讨中风痰瘀汤对急性缺血性脑卒中病人PDGF-BB、Ang-2表达的影响

Study on the effects of Zhongfeng Tanyu Decoction on the expression of PDGF-BB and Ang-2 in patients with acute ischemic stroke based on angiogenesis

摘要

摘要:
目的： 基于血管新生机制研究中风痰瘀汤对急性缺血性脑卒中风痰阻络型病人外周血小板衍生生长因子BB（PDGF-BB）、血管生成素2（Ang-2）表达的影响。
方法： 选择80例急性缺血性卒中病人80例，随机分为2组，每组40例，对照组给予急性脑梗死标准常规治疗。治疗组在对照组治疗基础上上予中风痰瘀汤。14d后，比较外周血清中PDGF-BB和Ang-2含量，观察比较2组病人治疗前后美国国立卫生研究院卒中量表评分（NIHSS评分）、脑卒中改良 Rankin 量表评分（mRS评分）、中医证候积分及ADL量表评分情况。
结果： 治疗后，2组病人的PDGF-BB水平较治疗前均明显升高（P ＜ 0.01），治疗组Ang-2水平较治疗前明显升高（P ＜ 0.01）。治疗组病人的PDGF-BB、Ang-2水平均较对照组均明显升高（P ＜ 0.01）。2组病人治疗后中医症状积分较治疗前均明显降低（P ＜ 0.01），ADL评分较治疗前均明显升高（P ＜ 0.01）。治疗后，与对照组比较，治疗组中医症状积分明显降低（P ＜ 0.01），ADL评分明显升高（P ＜ 0.01）。治疗后，2组病人NIHSS 评分较治疗前均下降（P ＜ 0.05），对照组mRS 评分较治疗前下降（P ＜ 0.05）。治疗后，治疗组病人的NIHSS评分与mRS 评分较对照组降低（P ＜ 0.05）。
结论： 中风痰瘀汤治疗中风痰阻络型急性缺血性脑卒临床疗效确切，其作用可能与其上调脑缺血损伤后PDGF-BB、Ang-2的表达的促进血管新生机制、改善脑部血供相关。

Abstract:
Objective To investigate the effects of Zhongfeng Tanyu Decoction on the vascular expression levels of Platelet-Derived Growth Factor BB (PDGF-BB) and Angiopoietin-2(Ang-2) in patients with acute ischemic stroke based on angiogenesis mechanism.
Methods A total of 80 patients with acute ischemic stroke were randomly divided into the control group and treatment group (40 cases each group). The control group were treated with standard conventional treatment, and the treatment group were treated with Zhongfeng Tan Yu Tang based on the control group. After 14 days, the serum levels of PDGF-BB and Ang-2 between two groups were compared, and the scores of National Institutes of Health Stroke Scale (NIHSS score), Stroke Modified Rankin Scale (mRS Score), TCM syndrome score and ADL scale before and after treatment were observed, and compared between two groups.
Results After treatment, the levels of PDGF-BB in two groups significantly increased compared with those before treatment (P ＜ 0.01), and the level of Ang-2 in the treatment group after was significantly higher than that before treatment (P ＜ 0.01). The levels of PDGF-BB and Ang-2 in the treatment group were significantly higher than those in control group (P ＜ 0.01). After treatment, the scores of traditional Chinese medicine symptoms significantly decreased (P ＜ 0.01), and the scores of ADL significantly increased in two groups compared with these before treatment (P ＜ 0.01). After treatment, the TCM symptom score in the treatment group significantly decreased (P ＜ 0.01), and the ADL score significantly increased compared with the control group (P ＜ 0.01). After treatment, the NIHSS scores in two groups decreased compared with before treatment (P ＜ 0.05), the mRS score in the control group decreased compared with before treatment (P ＜ 0.05). After treatment, the NIHSS and mRS Scores in the treatment group were lower than those in control group (P ＜ 0.05).
Conclusions Zhongfeng Tanyu decoction has definite clinical efficacy in treating stroke phlegm-blocked acute ischemic brain stroke, and its effect may be related to the mechanism of promoting angiogenesis and improving cerebral blood supply by up-regulating the expression of PDGF-BB and Ang-2 after cerebral ischemic injury.

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