妊娠期高血压疾病血清胱抑素C检测的临床意义

The clinical significance of serum levels of cysc detected in patients with hypertensive disorders of pregnancy

摘要: 目的: 探讨妊娠期高血压疾病(妊高病)患者血清中胱抑素C (cystatin C,CysC)的临床意义。方法: 测定90例妊高病患者观察组血清中CysC、血清肌酐(Cr)、尿素氮(BUN)、尿酸(UA)水平,并同正常未孕组30名、正常晚孕组30名血清中的CysC、Cr、BUN、UA水平进行对比。结果: 妊娠各组血清中CysC值均较未孕者高(P < 0.01),子痫前期重度组均较妊高病组、子痫前期轻度组及正常晚孕组明显增高(P < 0.01)。结论: 妊高病血清中CysC的水平可以反映妊高病早期肾功能损害情况,为其在产科的临床应用提供实验依据。

Abstract: Objective: To investigate the clinical significance of serum levels of serum cystatin C(CysC) determination in patients with hypertensive disorders of pregnancy. Methods: The patients were divided into three groups(hypertensive disorders of pregnancy,healthy nonpregnancy and late pregnancy). The serum levels of CysC,creatinine,urea nitrogen and uric acid were determined,and the results were statistically analyzed. Results: The serum levels of CysC in pregnancy were higher than nonpregnancy(P < 0.01). The serum levels of CysC in serious preeclampsia were higher than hypertensive disorders of pregnancy,mild preeclampsia and late pregnancy(P < 0.01). Conclusions: The serum levels of CysC were meaningful for the diagnosis of early kidney function damage.