耿新辉, 陈方剑, 于晶晶, 陈建国, 马涛, 李见春. 磷酸川芎嗪滴丸药物动力学研究[J]. 蚌埠医学院学报, 2007, 32(4): 403-405.
    引用本文: 耿新辉, 陈方剑, 于晶晶, 陈建国, 马涛, 李见春. 磷酸川芎嗪滴丸药物动力学研究[J]. 蚌埠医学院学报, 2007, 32(4): 403-405.
    GENG Xin-hui, CHEN Fang-jian, YU Jing-jing, CHEN Jian-guo, MA Tao, LI Jian-chun. Study on the pharmacokinetics of ligustrazine phosphate dripping pills in healthy volunteers[J]. Journal of Bengbu Medical College, 2007, 32(4): 403-405.
    Citation: GENG Xin-hui, CHEN Fang-jian, YU Jing-jing, CHEN Jian-guo, MA Tao, LI Jian-chun. Study on the pharmacokinetics of ligustrazine phosphate dripping pills in healthy volunteers[J]. Journal of Bengbu Medical College, 2007, 32(4): 403-405.

    磷酸川芎嗪滴丸药物动力学研究

    Study on the pharmacokinetics of ligustrazine phosphate dripping pills in healthy volunteers

    • 摘要: 目的: 探讨磷酸川芎嗪滴丸药物动力学特征。方法: 20名健康志愿者,单剂量口服磷酸川芎嗪滴丸200mg,采用高效液相色谱法(HPLC)测定血清中药物的浓度,DAS2.0程序计算药代动力学参数。结果: 磷酸川芎嗪滴丸主要药代动力学参数:Ka为(0.151±0.144) min,Tmax为(40.5±15.5) min,Cmax为(1.7±0.3)μg/ml,t1/2β为(67.7±3.2) min,CL/F为(0.017±0.004) L·min-1·kg-1,AUC0-300min为(181.5±40.3)μg·min-1·ml-1,AUC(0-∞)为(209.6±46.6)μg·min-1·ml-1结论: 单剂量口服磷酸川芎嗪滴丸200mg最佳房室模型为二室模型。

       

      Abstract: Objective: To studdy the pharmacokinetics of ligustrazine phosphate dripping pills.Methods: Twenty healthy volunteers were given a single oral dose of 200 mg ligustrazine phosphate dripping pills.The serum concentrations of ligustrazine were determined by high performance liquid chromatogram (HPLC).The pharmacokinetic parameters were calculated with DAS2.0 practical pharmacokinetics program.Results: The main pharmacokinetics parameters of ligustrazine phosphate dripping pills were as follows:Ka was (0.151±0.144) min, Tmax was (40.5±15.5) min, Cmax was (1.7±0.3) μg/ml, t1/2β was (67.7±3.2) min, CL/F was (0.017±0.004) L·min-1·kg-1, AUC 0-300 min was (181.5±40.3) μg·min-1·ml-1 and AUC(0-∞) was (209.6±46.6) μg·min-1·ml-1, respectively.Conclusions: The preparation fits the two-compartment model best.

       

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