Abstract: Objective: To investigate the bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery.Methods: Sixty elderly patients undergone lower limb surgery were randomly divided into bupivacaine group(A group,30 cases) and bupivacaine combined with sufentanil group(B group,30 cases).Group A and B were treated with the 0.5 ml mixture of 7.5 mg bupivacaine and 0.9% sodium chloride,and 0.4 ml mixture of 7.5 mg bupivacaine combined with 5 μg sufentanil and 0.9% sodium chloride,respectively.The onset time,degree and duration time of sensory block,and duration time of motor block,modified Bromage score,and the intraoperative and postoperative itching,nausea and vomiting in two groups were observed.Results: The differences of the onset time of sensory block,modified Bromage score,duration time of motor block and intraoperative and postoperative adverse reactions between two groups were not statistically significant(P>0.05).Compared with A group,the duration time and highest plane of sensory block in B group were significantly prolonged and high(P<0.01).Conclusions: The bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery is more safe and effective.