Abstract: Objective:To investigate the clinical effect of laparoscopic reparation on peptic ulcer perforation. Methods:The clinical data of 74 cases were retrospectively reviewed from 2005 to 2010. Thirty-six cases were performed with laparoscopic repair(laparoscopic group) and 38 cases underwent open surgery(open surgery group). The mean blood loss,mean surgery time,recovery of the stomach and intestines function,hospital stay,hospital cost and the rate of complications were observed. Results:Compared with the open surgery group,the mean blood loss,mean surgery time,recovery of the stomach and intestines function,and hospital stay in laparoscopic group had statistically significant difference (P<0.01), the rate of complications in laparoscopic group had no statistically significant difference(P>0.05). Conclusions:The laparoscopic repair in patients with peptic ulcer perforation is safety and effective,so it is worth to recommend its clinical use.