赵佑君, 金钟. 氯诺昔康复合芬太尼用于乳腺癌根治术后静脉镇痛的观察[J]. 蚌埠医学院学报, 2007, 32(6): 669-670.
    引用本文: 赵佑君, 金钟. 氯诺昔康复合芬太尼用于乳腺癌根治术后静脉镇痛的观察[J]. 蚌埠医学院学报, 2007, 32(6): 669-670.
    ZHAO You-jun, JIN Zhong. Clinical observation of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl[J]. Journal of Bengbu Medical College, 2007, 32(6): 669-670.
    Citation: ZHAO You-jun, JIN Zhong. Clinical observation of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl[J]. Journal of Bengbu Medical College, 2007, 32(6): 669-670.

    氯诺昔康复合芬太尼用于乳腺癌根治术后静脉镇痛的观察

    Clinical observation of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl

    • 摘要: 目的: 评价氯诺昔康复合小剂量芬太尼用于乳腺癌根治术后静脉自控镇痛(PICA)中的疗效与不良反应。方法: 选择ASAⅠ~Ⅱ级的乳腺癌根治术患者80例,随机分为两组,每组40例,氯诺昔康复合小剂量芬太尼组(L组)镇痛液为氯诺昔康56 mg、芬太尼0.3 mg加格拉斯琼3 mg,用生理盐水稀释至100 ml。曲马多组(T组)镇痛液为曲马多800 mg加格拉斯琼3 mg,用生理盐水稀释至100 ml。缝皮前给负荷量,L组为氯诺昔康8 mg,T组为曲马多100 mg(静脉滴注)后接镇痛泵,术后4 h、8 h、12 h、24 h和48 h观察并记录疼痛评分、镇静评分和副作用发生情况。结果: 两组间疼痛和镇静评分均无统计学意义(P>0.05)。恶心、呕吐和头晕副作用发生率L组均低于T组(P<0.01~P<0.05)。结论: 氯诺昔康复合小剂量芬太尼用于乳癌根治术后镇痛安全有效,且副作用小于曲马多。

       

      Abstract: Objective: To assess the analgesic and side effects of postoperative intravenous analgesia of radical mastectomy with lornoxican and fentanyl.Methods: Eighty grade Ⅰ-Ⅱ ASA patients of radical mastectomy were randomly divided into two groups:group L(n=40)received post operative intravenous analgesia with lornoxican and fentanyl while group T(n=40) received postoperative intravenous analgesia with tramadol.In group L,lornoxican 56 mg,fentanyl 0.3 mg and granisetron 3 mg were diluted with normal saline to 100 ml while in group T tramadol 800 mg and Granisetron 3 mg were diluted with normal saline to 100 ml.The patients received a loading dose,Group L:lornoxican 8 mg;group T:tramadol 100 mg,before suturing skin and then received the analgesia pump.Pain score(VAS 0-10),sedation score(0-3) and side effects were recorded at 4 h,8 h,12 h,24 h and 48 h after operation.Results: There was no significant difference in pain and sedation scores between the two groups(P>0.05).The incidence of side effects in Tramadol group was higher than that in lornoxican and fentanyl group(P<0.01-P<0.05).Conclusions: lornoxican and fentanyl are safe and effective in the treatment of postoperative pain of radical mastectomy,and have fewer side effects than Tramadol.

       

    /

    返回文章
    返回