Abstract: Objective: To investigate the curative effects of trimetazidine in the treatment of acute ischemic vascular dementia.Methods: Ninety-eight patients with acute ischemic vascular dementia were randomly divided into the treatment group and control group.The control group were treated with aspirin enteric-coated tablets,simvastatin,xuesaitong combined with oxiracetam for 3 weeks,the treatment group were additionally treated with 20 mg of trimetazidine by oral,3 times a day,based on the control group.The scores of MMSE,CDR and ADL before treatment and after 1,2 and 3 weeks of treatment and levels of TCH,TG and HCY before and after treatment in two groups were measured.Results: In treatment group,the MMSE score,and CDR and ADL scores increased and decreased gradually after 1,2 and 3 weeks of treatment,respectively.The differences of the all scores between before treatment and after 2 weeks of treatment in treatment group were statistically significant(P<0.01).After 3 weeks of treatment,the total effective rate in treatment group(83.7%) was higher than that in control group(20.4%)(P<0.01).Compared with before treatment,the levels of TCH,TG and HCY in treatment group and levels of TG and HCY in control group were significantly low after treatment(P<0.01).Conclusions: Trimetazidine can reduce the levels of TCH,TG and HCY.Trimetazidine can reduce and treat the ischemic vascular dementia,the treatment effect of which is significant after 2 weeks of treatment.