Abstract: Objective: To explore the perioperative risks and preventive measures of pernicious placenta praevia.Methods: Thirty cases with pernicious placenta praevia and 32 cases with non-pernicious placenta praevia were divided into the study group and control group from 2010 to 2013,respectively.The preoperative ultrasound,preoperative bleeding rate,intraoperative blood loss,placenta implantation rate,uterus resection rate,intraoperative hemostatic measures,neonatal asphyxia and postoperative recovery time between two groups were analysed.Results: The difference of preoperative ultrasound in two groups was statistical significance(P<0.01).There was not significant difference in preoperative bleeding rate and neonatal asphyxia between two groups(P>0.05).The differences of intraoperative blood loss,total amount of blood transfusion,intraoperative vital signs placenta implantation rate,uterus resection rate and intraoperative hemostatic measures between two groups were statistically significant(P<0.01).The differences of postoperative body temperature and hospital stay in two groups were statistically significant(P<0.01),and the difference of postoperative hemoglobin recovery in two groups was not statistically significant(P>0.05).Conclusions: The perioperative risk of pernicious placenta praevia is great,which need some collaboration rescue measures of multidisciplinary to ensure the safety of motherhood and infant.