Abstract: Objective: To evaluate the efficacy of mifepristone and gestrinone in treatment of patients with endometriosis after operation.Methods: One hundred and thirty-eight cases with endometriosis were randomly divided into three groups:Forty-six cases in mifepristone (12.5 mg/d) group,46 cases in gestrione (2.5 mg,twice a week) group,the treatment in these two groups was started at one week after the operation for 6 months and other 46 cases were in control group (without drug treatment),all of them were regularly followed-up.Results: The remission of symptoms of dysmenorrhoea in varying degree were seen in patients of these 3 groups.The complete remission rates in patients of mifepristone and gestrinone groups were significantly higher than of control group (P<0.01).The recurrence rates in mifepristone and gestrinone groups were significantly lower than of control group (P<0.01).Conclusions: The consolidation therapy with mifepristone and gestrinone for post-operation treatment of endometriosis is safe and effective with less adverse reactions.