Abstract: Objective:To observe the clinical efficacy of L-carnitine combined with hemodialysis in the treatment of uremic peripheral neuropathy.Methods:Seventy-six patients with uremic peripheral neuropathy were randomly divided into the control group and observation group(38 cases each group).The control group and observation group were treated with ordinary hemodialysis and L-carnitine combined with hemodialysis,respectively.The curative efficacy and nerve conduction velocity between two groups were compared.Results:Compared with before treatment,the sensory nerve conduction velocity in observation group significantly increased(P<0.01),and the level of which was significantly higher than that in control group after treatment(P<0.01).The total effective rate in observation group(86.8%) was significantly higher than that in control group(57.9%)(P<0.01).Conclusions:The treatment of uremic patients with peripheral neuropathy with L-carnitine combined with hemodialysis can significantly improve the symptom of patients,which is effective and simple.