Abstract: Objective: To enhance the cognition of the premature infant hypoxic ischemic encephalopathy(HIE) on CT manifestations.Methods: Twenty-eight premature infants diagnosed as HIE were performed using CT scan and their CT images were analyzed.Results: All the 28 cases of HIE showed low density edema area in the brain white matter.Of the 14 minor cases,2 were accompanied by intraventricular hemorrhage(IVH) and 3 by subarachnoid hemorrhage(SAH);Of the 9 moderate cases,1 was accompanied by SAH;Of the 5 sever cases,2 were accompanied by IVH.Conclusions: The brain edema and intracranial hemorrhage in the premature infant HIE can be detected by CT scan,which is of great benefit to the clinical diagnosis and treatment.