Abstract: Objective: To assess the value of loop electrocacctery excision procedure(LEEP) with high-frequency electric-wave knives in treatment of cervical pathological changes.Methods: Sixty-three cases diagnosed abnormal by cytology and colposcopy were divided into LEEP group(33 cases) and traditional electric knife group(30 cases).Results: Cytological examination was performed three months after LEEP operation.The durative existing ratio of pathological changes was 6.1% in the LEEP group,which was similar to 6.7% in the traditional electric knife group.The duration of surgery(5.0±0.5)min of the LEEP group was shorter than that(15.0±0.5)min of traditional electric knife group.Duration of bleeding and time of cervice repairing was shorter in the LEEP group than that in the traditional electric knife group(P<0.01).Conclusions: LEEP is a simple and safe procedure for treatment of cervical pathological changes with a high success rate.It is worth popularizating.