Abstract: Objective: To investigate the effects of the level of plasma homocysteine(Hcy) on the cognitive impairment after acute cerebral infarction.Methods: A total of 228 consecutive patients with acute cerebral infarction were enrolled and divided into the non-cognitive impairment group and cognitive impairment group according to the Montreal cognitive assessment.The potential risk factors of the cognitive impairment in two groups were analyzed using univariate analysis method,the significant indicators of which was analzyed using logistic regression analysis method,and the relative risk degree of the cognitive impairment after cerebral infarction was assessed by the level of plasma Hcy.Results: Logistic regression analysis showed that the age,education level,diabetes and Hcy level(the OR value for 0.94,1.21,1.86 and 2.35) were the independent influence factors of cognitive impairment after acute cerebral infarction.The level of Hcy in cognitive impairment group(14.87±5.85)μmol/L was significantly higher than that in non-cognitive impairment group(12.78±5.68) μmol/L(P<0.01).The incidence rate of the cognitive impairment in patients with hyperhomocysteinemia was higher than that in patients without hyperhomocysteinemia,and the relative risk degree and 95%CI value of patients with hyperhomocysteinemia to those without hyperhomocysteinemia were 1.92,and 1.125 to 3.289,respectively.Conclusions: Plasma Hcy is the important influence factor of cognitive impairment after acute cerebral infarction.Hyperuricemia increases the risk of the cognitive impairment in cerebral infarction patients.