Abstract: Objective: To explorethe means of the peripherally inserted central catheter(PICC) through axillary vein and its effects on complications.Methods: One hundred and forty cases treated with PICC through axillary vein and 139 cases through other location were set as the observation group and control groups,respectively.The success rate of once puncture,delivery problem,ectopic rate in the first time and incidence of ectopic correct in place in two groups were compared.Results: The success rates of once puncture and ectopic correct in place in observation group were significantly higher than those in control group(P<0.01).The incidence of piercing difficulty in observation group was obviously lower than that in control group(P<0.01).The difference of the ectopic rate between two groups was not statistically different(P>0.05).Conclusions: Compared with PICC through other location,the PICC through axillary vein can improve the success rates of once puncture and ectopic correct in place and decrease the incidence of piercing difficulty,which is worth popularizing in neonatal PICC.