慢性阻塞性肺疾病营养状况与甲状腺激素水平的关系

    Study on the correlation between nutrition status and thyroid hormone in patients with chronic obstructive pulmonary disease

    • 摘要: 目的: 探讨慢性阻塞性肺疾病(COPD)患者营养状况与甲状腺激素水平的关系。方法: COPD临床稳定期患者148例和健康对照组30名,根据体重指数(BMI)、理想体重百分比(NW%)、三头肌皮皱厚度(TSF)、上臂中点臂围(MAC)、血清白蛋白(ALB)、总淋巴细胞(LYM)等营养参数,将COPD患者分为COPD营养不良组(COPDⅠ组)47例和COPD非营养不良组(COPDⅡ组)101例。采用放射免疫法检测甲状腺激素,并探讨相互之间的相关关系。结果: COPDⅠ组BMI、NW%、TSF、MAC、ALB、LYM、T3、T4均低于COPDⅡ组、对照组(P < 0.01),除对照组T4高于COPDⅡ组外,其余2组各指标差异均无统计学意义(P > 0.05);所有营养参数与T3均呈正相关关系(P < 0.05~P < 0.01),ALB仅与T4呈正相关关系(P < 0.05)。结论: 甲状腺激素水平与COPD患者营养状况密切相关。

       

      Abstract: Objective: To investigate the correlation between nutrition status and thyroid hormone in the patients with chronic obstructive pulmonary disease (COPD). Methods: One hundred and forty-eight COPD patients in stable stage and 30 normal controls were studied. Nutritional parameters,including body mass index (BMI),percentage of normal body mass (NM%),triceps skin-fold thickness (TSF),mid-upper arm circumference (MAC),serum albumin (ALB),and total lymphocyte counts (LYM) were determined. COPD patients were divided into malnutrition group (groupⅠ,47 cases) and non-malnutrition group (group Ⅱ,101 cases) according to these nutritional parameters. Thyroid hormones (including T3,T4 and TSH) were detected by radioimmunoassay method. The correlation between these parameters were analyzed. Results: In contrast to control group and groupⅡ,there were significant differences on BMI,NW%,TSF,MAC,ALB,LYM,T3 and T4 in group Ⅰ(P < 0.01). Except that T4 in control group was higher than group Ⅱ,there were no significant difference on these parameters between the two groups (P > 0.05). Significant correlation was existed between T3 and all nutritional parameters (P < 0.05-P < 0.01),T4 was only linked to albumin (P < 0.05). Conclusions: There is significant correlation between thyronine and nutritional status in patients with COPD.

       

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