Abstract: Objective: To investigate the clinical therapy for early-onset severe preeclampsia. Methods: The clinical data of 81 patients with early-onset severe preeclampsia and their 85 neonates were analyzed retrospectively. The cases were divided into three groups according to the onset gestation age. Group A included 9 cases between 24-27⁺⁶ weeks,group B 46 cases between 28-31⁺⁶ weeks and group C 26 cases between 32-34 weeks. The general condition,complication and outcome of both mothers and infants were observed. Results: The gestation age was prolonged about (10.0 ±3.1) days in group A,(13.7 ±5.2) days in group B and (12.6 ±3.5) days in group C,respectively. There were no significant differences in clinical symptoms or complications among the three groups(P > 0.05). The neonatal asphyxia rate and perinatal infant mortality in the three groups declined with the gestation age. And the differences were statistically significant(P < 0.05-P < 0.01). Conclusions: During the expectant treatment,the condition of maternity and fetus should be closely monitored,and pregnancy termination should be decided timely.