Abstract: Objective: To summarize the experience of tetralogy of Fallot radical operation in infants,improve surgical technique and reduce mortality.Methods: The clinical data of 77 cases treated with tetralogy of Fallot radical operation were retrospectively analyzed.Pure right ventricular outflow tract patch in 15 cases and pulmonary valve ring patch in 62 cases were implentmented through median incision under the condition of middle and low temperature/profound hypothermia low flow.Results: One case died after the operation,which was mainly caused by low cardiac output syndrome,other cases with ventilator-associated pneumonia,arrhythmia,cardiac tamponade and pleural effusions were cured.None died during the period of following-up for 3 to 24 months.Conclusions: The effects of radical operation in the treatment of tetralogy of Fallot in infants are good.Early correcting cardiac malformation and strengthening postoperative management can effectively reduce the mortality rate of infants.