Abstract: Objective: To investigate the curative effect of irbesartan/hydrochlorothiazide combination on the mild to moderate hypertension patients with left ventricular hypertrophy.Methods: By using self control,the 78 cases of mild to moderate hypertension with left ventricular hypertrophy were confirmed by echocardiography,then they were treated with irbesartan/hydrochlorothiazide combination orally two pieces once a day in the morning,and it was lasted for three months.The correlated data of left ventricle were tested by multicolor hyperacoustic Doppler before and after treatment.The left ventricular mass index(LVMI) was calculated and the changes of the LVMI and heart function parameters were analysed.Results: The systolic pressure and diastolic pressure were decreased significantly after treatment(P<0.001).The inner diameter of the left ventricular end-diastole,the thickness of the posterior left ventricular wall and the interventricular septum were decreased significantly(P<0.001).The left ventricular quality and LVMI were decreased more significantly(P<0.001).Conclusions: After three months treatment of irbesartan/hydrochlorothiazide combination,the symptom of left ventricular hypertrophy was significantly reversed in the mild to moderate hypertension patients,meanwhile the diastolic function of left ventricle was improved.It is securely and effectively.