Abstract: Objective: To observe the examination results and characteristics of cerebrospinal fluid(CSF) and electroencephalogram(EEG) in children with hand,foot and mouth disease(HFMD) within 1 to 2 days after admission.Methods: The white blood cell count,protein,sugar and chloride in the CSF of 89 children with HFMD were monitored;at the same time,EEG examination was carried out.Results: The CSF of severe HFMD conformed to that of viral encephalitis,and the abnormal rate was 74.16%.There was no significant difference in the CSF cell count and biochemical examination in cases with severe HFMD and grave HFMD receiving ventilator treatment(P>0.05).The EEG of 57 children with HFMD was abnormal.The abnormal rate of CSF was higher than that of EEG.Conclusions: There is a high abnormal rate of CSF and EEG in HFMD children with neurological symptoms,so early CSF and EEG examinations are recommended.