Abstract: Objective: To summarize the surgical experience and therapeutic effect for substernal goiter.Methods: Twenty-one cases with substernal goiter were operated with resection method.One case of thyroid cancer was treated with radical resection,the other 20 cases of thyroid benign tumor were treated with subtotal thyroidectomy.Results: No operative or hospitalized death occurred;one case was complicated with recurrent laryngeal nerve injury,and postoperative recovery was in three months.Two cases was with transient tetany,postoperative recovery was in in two months.Conclusions: Goiter can be excised by way of neck with satisfactory prognosis,and there is no need to open the chest.