郭冰沁, 俞岚. 卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系[J]. 蚌埠医学院学报, 2007, 32(4): 381-383,506.
    引用本文: 郭冰沁, 俞岚. 卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系[J]. 蚌埠医学院学报, 2007, 32(4): 381-383,506.
    GUO Bing-qin, YU Lan. Expression of MMP-2、MMP-9 and VEGF-C in ovarian cancer and its correlation with the biological behavior[J]. Journal of Bengbu Medical College, 2007, 32(4): 381-383,506.
    Citation: GUO Bing-qin, YU Lan. Expression of MMP-2、MMP-9 and VEGF-C in ovarian cancer and its correlation with the biological behavior[J]. Journal of Bengbu Medical College, 2007, 32(4): 381-383,506.

    卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系

    Expression of MMP-2、MMP-9 and VEGF-C in ovarian cancer and its correlation with the biological behavior

    • 摘要: 目的: 探讨卵巢癌组织中MMP-2、MMP-9与VEGF-C的表达与卵巢癌临床病理生物学行为的关系以及它们之间的相关性。方法: 应用免疫组化方法对97例卵巢乳头状癌组织进行MMP-2、MMP-9与VEGF-C蛋白的检测。结果: MMP-2、MMP-9与VEGF-C的表达与乳头状癌的组织学类型无关(P>0.05);临床分期Ⅲ、Ⅳ期的表达均高于Ⅰ、Ⅱ期(P<0.005~P<0.05);Ⅰ级、Ⅱ级和Ⅲ级的MMP-2阳性表达率分别为40.9%、76.9%和91.7%,MMP-9阳性表达率分别为40.9%、79.5%和94.4%,VEGF-C阳性表达率分别为13.6%、66.7%和72.2%,其阳性表达率均随着恶性肿瘤分级增高而显著增加(P<0.005),有腹腔淋巴结转移者均高于无转移者(P<0.005~P<0.05)。卵巢癌中,VEGF-C表达与MMP-2、MMP-9的表达均呈正相关关系(P<0.05)。结论: MMP-2、MMP-9与VEGF-C的过表达促进卵巢癌的浸润和转移,VEGF-C表达与MMP-2、MMP-9表达分别具有正协同作用。联合检测MMP-2、MMP-9、VEGF-C蛋白可作为预测卵巢癌浸润转移及评价患者预后的生物学指标。

       

      Abstract: Objective: To explore the association of the expression of MMP-2, MMP-9 and VEGF-C with the clinicobiologic behavior in ovarian carcinoma.Methods: Immunohistochemical staining was used to detect the expression of MMP-2, MMP-9 and VEGF-C in 97 cases of ovarian cancer.Results: The positive expression of MMP-2, MMP-9 and VEGF-C had no relationship with histological typing of ovarian carcinoma (P>0.05).But the expressions of the three markers were higher in clinical stage Ⅰ, Ⅱ than that in stage Ⅲ, Ⅳ (P<0.005 to P<0.05), and which were increased with the grading (P<0.005 to P<0.05).And the expressions were higher in patients with lymph node involvement than those without ones (P<0.05 to P<0.005).In ovarian carcinoma, the expression VEGF-C had positive direct correlation to both the expression of MMP-2 and MMP-9 (P<0.05).Conclusions: The expression of MMP-2 and MMP-9 with cooperative of VEGF-C promote invasion and metastasis of ovarian carcinomas, and thus can be used as markers to predict invasion and metastasis of ovarian carcinomas and the prognosis of these patients as well.

       

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