卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系

郭冰沁; 俞岚

卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系

郭冰沁,
俞岚

Expression of MMP-2、MMP-9 and VEGF-C in ovarian cancer and its correlation with the biological behavior

摘要

摘要: 目的: 探讨卵巢癌组织中MMP-2、MMP-9与VEGF-C的表达与卵巢癌临床病理生物学行为的关系以及它们之间的相关性。方法: 应用免疫组化方法对97例卵巢乳头状癌组织进行MMP-2、MMP-9与VEGF-C蛋白的检测。结果: MMP-2、MMP-9与VEGF-C的表达与乳头状癌的组织学类型无关(P>0.05);临床分期Ⅲ、Ⅳ期的表达均高于Ⅰ、Ⅱ期(P<0.005~P<0.05);Ⅰ级、Ⅱ级和Ⅲ级的MMP-2阳性表达率分别为40.9%、76.9%和91.7%,MMP-9阳性表达率分别为40.9%、79.5%和94.4%,VEGF-C阳性表达率分别为13.6%、66.7%和72.2%,其阳性表达率均随着恶性肿瘤分级增高而显著增加(P<0.005),有腹腔淋巴结转移者均高于无转移者(P<0.005~P<0.05)。卵巢癌中,VEGF-C表达与MMP-2、MMP-9的表达均呈正相关关系(P<0.05)。结论: MMP-2、MMP-9与VEGF-C的过表达促进卵巢癌的浸润和转移,VEGF-C表达与MMP-2、MMP-9表达分别具有正协同作用。联合检测MMP-2、MMP-9、VEGF-C蛋白可作为预测卵巢癌浸润转移及评价患者预后的生物学指标。

Abstract: Objective: To explore the association of the expression of MMP-2, MMP-9 and VEGF-C with the clinicobiologic behavior in ovarian carcinoma.Methods: Immunohistochemical staining was used to detect the expression of MMP-2, MMP-9 and VEGF-C in 97 cases of ovarian cancer.Results: The positive expression of MMP-2, MMP-9 and VEGF-C had no relationship with histological typing of ovarian carcinoma (P>0.05).But the expressions of the three markers were higher in clinical stage Ⅰ, Ⅱ than that in stage Ⅲ, Ⅳ (P<0.005 to P<0.05), and which were increased with the grading (P<0.005 to P<0.05).And the expressions were higher in patients with lymph node involvement than those without ones (P<0.05 to P<0.005).In ovarian carcinoma, the expression VEGF-C had positive direct correlation to both the expression of MMP-2 and MMP-9 (P<0.05).Conclusions: The expression of MMP-2 and MMP-9 with cooperative of VEGF-C promote invasion and metastasis of ovarian carcinomas, and thus can be used as markers to predict invasion and metastasis of ovarian carcinomas and the prognosis of these patients as well.

HTML全文

参考文献(0)

施引文献

资源附件(0)