Abstract: Objective: To explore the influence of psychological intervention on the quality of life of patients with breast cancer.Methods: One hundred and twenty breast cancer patients were randomly divided into intervention and control groups.The clinical psychological intervention was performed on patients in intervention groups for 20 days,and just the routine therapy and care were performed on patients in control groups.World Health Organization Quality of Life with 100 questions(WHOQLQ-100) was used to observe the influence of psychological intervention on the quality of life of breast cancer patients.Results: The quality of life in intervention groups was obviously higher than that in control groups(P<0.05~P<0.01).Conclusions: The quality of life in breast cancer patients will increase evidently after receiving the psychological intervention.