Relation between the expressions of estrogen receptor subtypes and prognosis of endometrial carcinoma
-
摘要: 目的:探讨雌激素受体亚型在子宫内膜癌组织中的表达及其与子宫内膜癌预后因素的关系。方法:应用免疫组化S-P法检测36例正常子宫内膜、62例子宫内膜癌组织中雌激素受体亚型ERα、ERβ的表达,分析其与子宫内膜癌预后的关系。结果:子宫内膜癌组织中ERα阳性表达率为29.0%,明显低于正常子宫内膜的83.3%(P<0.01);子宫内膜癌组织中ERβ阳性表达率22.6%,与正常子宫内膜的27.8%相比,差异无统计学意义(P>0.05);ERα的表达与手术-病理分期、细胞分化程度和淋巴结转移均有一定关系(P<0.05)。结论:ERα在子宫内膜癌的发生、发展过程中起主导作用,ERα低表达可能是子宫内膜癌预后不良的指标。Abstract: Objective: To determine the expressions of ERα and ERβ in endometrial carcinoma and to investigate their correlation with the prognosis.Methods: The expressions of ERα and ERβ in 36 normal endometria and 62 endometrial carcinomas were determined by immunohistochemical staining S-P method,and their association with the prognosis of endometrial carcinoma was analyzed.Results: The positive expression of ERα in endometrial carcinoma was 29.0%,which was significantly lower than that in normal endometria(83.3%) (P<0.01);the expression of ERβ was 22.6% and 27.8% in endometrial carcinoma and normal endometria,respectively.The difference was not significant(P>0.05).The expression of ERα in endometrial carcinoma was significantly associated with the surgical stage,differentiation and lymphatic invasion(P<0.05).Conclusions: ERα plays an important role in the genesis and development of endometrial carcinoma,and low expression of ERα may indicate poor prognosis.
-
Keywords:
- uterine neoplasms /
- immunohistochemistry /
- receptor,estrogen /
- prognosis
-
计量
- 文章访问数: 3193
- HTML全文浏览量: 321
- PDF下载量: 1
下载:
