Abstract: Objective:To explore the application feasibility of etomidate emulsions combined with sufentanil continue pumping in laparoscopic cholecystectomy (LC).Methods:Fifty patients in ASA Ⅰ-Ⅱ who undergone elective LC were randomly divided into trial group (E group,n=25) and control group (P group,n=25).The patients in E group were pumped continuously with etomidate emulsions 0.6-0.9 mg·kg^-1·h^-1 combined with sufentanil 0.2 μg·kg^-1·h^-1·The patients in P group were pumped continuously with propofol 4-6 mg·kg^-1·h^-1 combined with sufentanil 0.2 μg·kg^-1·h^-1·All patients in these two groups were continuous infused with rocuronium 5-6 μg·kg^-1·min^-1.Heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP),postoperative decannulation time,postoperative recovery condition,state of consciousness post anesthesia care unit leave time,restlessness,postoperative nausea and vomiting,cough,laryngospasm,choking intraoperative awareness as adverse reaction conditions were recorded before narcotic induction narcotic induction (T₀),immediately (T₁),during tracheal intubation (T₂),gasless 5 min (T₃),15 min (T₄),after the lift gasless 5 min (T₅).Results:The hemodynamics indexes at all time points between the two groups were no statistical significance.The detubation time,consciousness recovery and the incidence rate of adverse reactions between these two groups were no statistical significance.Conclusions:Etomidate emulsions sufentanil compound can be used safely in LC anesthesia.