侧脑室注射内吗啡肽-1对大鼠心功能的影响

Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats

摘要: 目的: 观察侧脑室注射内吗啡肽-1(EM-1)对麻醉大鼠心功能的影响,探讨其作用机制。方法: 麻醉大鼠侧脑室埋植导管给药,右颈总动脉插管测心功能。结果: 侧脑室注射EM-1,Cyprodime敏感减弱大鼠左心室功能。结论: 侧脑室注射EM-1能引起麻醉大鼠在体心功能下降而降低动脉血压,此效应由阿片受体介导,通过兴奋迷走神经所致。

Abstract: Objective: To observe the influence of intracerebroventricular administraction of endomorphine-1 on the left venteicular systolic pressuer(LVSP) in anesthetized rats and to assess its mechanism.Methods: Variations of LVSP were observed after injecting endomorphin-1 in anesthetized rats.Results: Endomorphin-1 decreased the LVSP.The decrease in LVSP was blocked by cyprodime.Conclusions: Intracerebroventricular administration of endomorphin-1 produces depression on the LVSP in the anesthetized rats,which is mediated by opioid receptor,associated with the central mcholinoceptor and the excitation of the vagus.