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不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察

朱凡, 沈亮, 傅维安

朱凡, 沈亮, 傅维安. 不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察[J]. 蚌埠医科大学学报, 2004, 29(1): 34-35.
引用本文: 朱凡, 沈亮, 傅维安. 不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察[J]. 蚌埠医科大学学报, 2004, 29(1): 34-35.
ZHU Fan, SHEN Liang, FU Wei-an. Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade[J]. Journal of Bengbu Medical University, 2004, 29(1): 34-35.
Citation: ZHU Fan, SHEN Liang, FU Wei-an. Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade[J]. Journal of Bengbu Medical University, 2004, 29(1): 34-35.

不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察

详细信息
    作者简介:

    朱凡(1977-),女,上海人,住院医师.

  • 中图分类号: R971.91

Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade

  • 摘要: 目的: 观察不同剂量的新斯的明拮抗国产阿曲库铵肌松效应。方法: 30例ASA Ⅰ~Ⅱ级择期手术患者分为3组,每组10例,分别给新斯的明20 μg/kg (N20)、35 μg/kg (N35)、50 μg/kg (N50)拮抗国产阿曲库铵肌松作用,并测定各组TOF0.70的时间。结果: 新斯的明20 μg/kg产生的肌松恢复弱于35 μg/kg和50 μg/kg。而35 μg/kg和50 μg/kg所产生的肌松拮抗效果相似。结论: 新斯的明剂量由20 μg/kg增加到50 μg/kg时,肌松拮抗加快,35 μg/kg为较理想剂量。
    Abstract: Objective: To investigate the effect of dose of neostigmine administration on recovery from atracrium induced neuromuscular blockade.Methods: Thirty patients(ASA Ⅰ and Ⅱ) were divided into three groups(each ten),and received neostigmine 20 μg/kg,35 μg/kg and 50 μg/kg,respectively.Results: The speed of recovery from atracurium induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg.Conclusions: Recovery from atracurium-induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of atracurium induced neuromuscular blockade.
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出版历程
  • 收稿日期:  2003-06-19

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